diethyl 4-((6R,8S)-8-methyl-9-oxo-5,6,8,9-tetrahydrothiepino[4,5:4,5]benzo[1,2-d][1,3]dioxole-6-carboxamido)benzylphosphonate
diethyl 4-((6R,8S)-8-methyl-9-oxo-5,6,8,9-tetrahydrothiepino[4,5:4,5]benzo[1,2-d][1,3]dioxole-6-carboxamido)benzylphosphonate
CAS: 180185-61-9
Molecular Formula: C24H28NO7PS
diethyl 4-((6R,8S)-8-methyl-9-oxo-5,6,8,9-tetrahydrothiepino[4,5:4,5]benzo[1,2-d][1,3]dioxole-6-carboxamido)benzylphosphonate - Names and Identifiers
| Name | diethyl 4-((6R,8S)-8-methyl-9-oxo-5,6,8,9-tetrahydrothiepino[4,5:4,5]benzo[1,2-d][1,3]dioxole-6-carboxamido)benzylphosphonate |
| Synonyms | Phosphonic acid, P-[[4-[[[(6R,8S)-5,6,8,9-tetrahydro-8-methyl-9-oxothiepino[4,5-f]-1,3-benzodioxol-6-yl]carbonyl]amino]phenyl]methyl]-, diethyl ester |
| CAS | 180185-61-9 |
diethyl 4-((6R,8S)-8-methyl-9-oxo-5,6,8,9-tetrahydrothiepino[4,5:4,5]benzo[1,2-d][1,3]dioxole-6-carboxamido)benzylphosphonate - Physico-chemical Properties
| Molecular Formula | C24H28NO7PS |
| Molar Mass | 505.52 |
| Density | 1.334±0.06 g/cm3(Predicted) |
| Melting Point | 181-182 °C |
| Boling Point | 742.3±60.0 °C(Predicted) |
| pKa | 13.12±0.70(Predicted) |
| Storage Condition | Room Temprature |
| In vitro study | TAK-778 is a derivative of ipriflavone and has been shown to induce bone growth in in vitro and in vivo models. Continuous treatment with TAK-778 (10 μM) for 1 to 21 days results in an increase in the area of mineralized nodules. TAK-778 at concentrations of 1 μM and higher significantly stimulates the activity of cellular Alkaline phosphatase (ALP). TAK-778 increases slightly but significantly the DNA content of the cells at the confluence stage. Treatment with TAK-778 also results in dose-dependent increases in the amount of soluble collagen and osteocalcin secreted into culture medium from days 5 to 7. TAK-778 enhances the secretion of both TGF-β and IGF-I at every time point during the 21 days of culture. Treatment of the cells with TAK-778 does not induce ALP activity, but does result in a dose-dependent increase in the saturated cell density. TAK-778 at a concentration of 10 μM significantly reduces the saturated cell density. |
| In vivo study | Treatment with a single local application of TAK-778/PLGA-MC (0.2 to 5 mg/site) results in a dose-dependent increase in the radio-opaque area formed in the defect. Histological studies show the defect area is occupied by a bony bridge and the newly-formed radio-opaque area corresponds to a calcified bone containing bone marrow cavities surrounded by thick osteoid seams with cuboidal osteoblasts. There is no significant difference in either of the indices between placebo- or TAK-778/PLGA-MC-treated skulls. Two months after the operation, the TAK-778/PLGA-MC pellets induce radiological osseous union across the defects. Oral treatment of OVX rats with TAK-778 causes a more pronounced increase in bone mineral density (BMD) of the lumbar vertebrae compare to vehicle controls. |
diethyl 4-((6R,8S)-8-methyl-9-oxo-5,6,8,9-tetrahydrothiepino[4,5:4,5]benzo[1,2-d][1,3]dioxole-6-carboxamido)benzylphosphonate - References
| biological activity | TAK-778 is a derivative of ipriflavone that has been shown to induce bone growth in both in vitro and in vivo models. |
Last Update：2024-04-09 21:04:16
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Product Name: diethyl 4-((6R,8S)-8-methyl-9-oxo-5,6,8,9-tetrahydrothiepino[4,5:4,5]benzo[1,2-d][1,3]dioxole-6-carboxamido)benzylphosphonate Visit Supplier Webpage Request for quotation
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View History
diethyl 4-((6R,8S)-8-methyl-9-oxo-5,6,8,9-tetrahydrothiepino[4,5:4,5]benzo[1,2-d][1,3]dioxole-6-carboxamido)benzylphosphonate
3-(4-chlorophenyl)-6-(4-methoxyphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
4,6-dichloro-N-cyclohexyl-1,3,5-Triazin-2-amine
Benzenesulfonamide, 3-chloro-2-(1H-1,2,4-triazol-1-yl)-
benzyl 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
338777-17-6
1261967-65-0
55444-88-7
4-(7-Acetyl-4,6-dihydroxy-3,5-dimethylbenzofuran-2-yl)-2-(1-hydroxyethylidene)-3-oxobutyric acid ethyl ester
1-(2,3-Dihydrobenzofuran-5-yl)-2,2,2-trifluoroethan-1-ol
3-(4-chlorophenyl)-6-(4-methoxyphenyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
4,6-dichloro-N-cyclohexyl-1,3,5-Triazin-2-amine
Benzenesulfonamide, 3-chloro-2-(1H-1,2,4-triazol-1-yl)-
benzyl 6-methyl-4-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
338777-17-6
1261967-65-0
55444-88-7
4-(7-Acetyl-4,6-dihydroxy-3,5-dimethylbenzofuran-2-yl)-2-(1-hydroxyethylidene)-3-oxobutyric acid ethyl ester
1-(2,3-Dihydrobenzofuran-5-yl)-2,2,2-trifluoroethan-1-ol